VASH1 Antikörper (C-Term)

Produktnummer ABIN783478

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch VASH1 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für VASH1 Antikörper (C-Term) (ABIN783478)

Target: VASH1 (Vasohibin 1 (VASH1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VASH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-VASH1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detctes Vasohibin-1 / VASH1 at C-term. VASH1 antibody is predicted to not cross-react with other vasohibin protein family members. At least two isoforms are known to exist, this antibody will recognize only the long isoform.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the carboxy terminus of human VASH1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu VASH1

Target: VASH1 (Vasohibin 1 (VASH1))

Andere Bezeichnung: Vasohibin-1 / VASH1

Hintergrund: VASH1 was originally identified as an endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor that acts in a negative feedback manner. VASH1 mRNA is expressed brain, heart, kidney and placenta in the adult, with robust expression in various organs during embryonic development. VASH1 expression in tumor cells and tumor vasculature is silenced by methylation by increased expression of Zeste homolog 2 (EZH2). The increase of EZH2 expression is induced by VEGF stimulation, leading to poor clinical prognosis. Recombinant adenovirus expressing VASH prevented tumor angiogenesis and inhibited tumor growth, suggesting that it may be a potentially valuable antitumor therapy in the clinic.Synonyms: KIAA1036, VASH

Gen-ID: 22846

NCBI Accession: NP_055724

UniProt: Q7L8A9