SIK2 Antikörper (Center)

Produktnummer ABIN783466

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SIK2 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für SIK2 Antikörper (Center) (ABIN783466)

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-SIK2 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody detects SIK2 at Center. SIK2 antibody is predicted to not cross-react with other SIK protein family members.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the center of human SIK2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu SIK2

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Andere Bezeichnung: SIK2

Hintergrund: Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1?alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.Synonyms: QIK, Qin-induced kinase, SIK-2, SNF1LK2, Salt-inducible protein kinase 2, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SNF1-like kinase 2

Gen-ID: 23235

NCBI Accession: NP_056006

UniProt: Q9H0K1