SIK2 Antikörper (Center)

Produktnummer ABIN783466

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch SIK2 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für SIK2 Antikörper (Center) (ABIN783466)

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-SIK2 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody detects SIK2 at Center. SIK2 antibody is predicted to not cross-react with other SIK protein family members.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the center of human SIK2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu SIK2

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Andere Bezeichnung: SIK2

Hintergrund: Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1?alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.Synonyms: QIK, Qin-induced kinase, SIK-2, SNF1LK2, Salt-inducible protein kinase 2, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SNF1-like kinase 2

Gen-ID: 23235

NCBI Accession: NP_056006

UniProt: Q9H0K1