SIK1 Antikörper (Center)

Produktnummer ABIN783464

Produktdetails anti-SIK1 Antikörper

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Bindungsspezifität: Center

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects SIK1 at Center. Two isoforms of SIK1 are known to exist, this antibody will detect both isoforms. SIK1 antibody is predicted to not cross-react with other SIK protein family members.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the center of human SIK1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Referenzen für anti-SIK1 Antikörper (ABIN783464)

Chen, Shen, Wu, Hua, Kuang, Li, Peng: "CISD2 associated with proliferation indicates negative prognosis in patients with hepatocellular carcinoma." in: International journal of clinical and experimental pathology, Vol. 8, Issue 10, pp. 13725-38, (2016) (PubMed).

Details zu SIK1

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Andere Bezeichnung: SIK1 (SIK1 Produkte)

Synonyme: Msk antikoerper, Sik antikoerper, Snf1lk antikoerper, SIK2 antikoerper, SNF1LK antikoerper, MSK antikoerper, SIK antikoerper, salt-inducible kinase 1 antikoerper, salt inducible kinase 1 antikoerper, SIK1 antikoerper, Sik1 antikoerper

Hintergrund: Salt-inducible kinase 1 (SIK1), also known as SNF1LK or MSK, plays a role in histone modification and G2/M cell cycle regulation. It is a 783 amino acid protein that contains one UBA domain and belongs to the Ser/Thr protein kinase family (AMPK subfamily). Localized to both the nucleus and the cytoplasm, SIK1 is a class II HDAC kinase that uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be important for the early stages of skeletal muscle growth and myocardial cell differentiation.Synonyms: SIK, SIK-1, SNF1LK, Salt-inducible protein kinase 1, Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SNF1-like kinase 1

Gen-ID: 150094

NCBI Accession: NP_775490

UniProt: P57059

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process