EZH2 Antikörper (N-Term)

Produktnummer ABIN783462

Der Kaninchen Polyklonal anti-EZH2 Antikörper (ABIN783462) detektiert spezifisch EZH2 in WB und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für EZH2 Antikörper (N-Term) (ABIN783462)

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EZH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-EZH2 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects EZH2 / KMT6 N-term. EZH2 antibody is predicted to not cross-react with EZH1.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the amino terminus of human EZH2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu EZH2

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Andere Bezeichnung: EZH2 / KMT6

Hintergrund: EZH2 was initially identified as a homolog of the drosophila Enhancer of Zeste through exon trap screening of chromosome 21. Both EZH2 and the related protein EZH1 can form complexes with the noncanonical Polycomb repressive complex-2 (PRC2) and maintain repressive chromatin, but the PRC2-EZH1 complex mediates methylation of histone H3. Both EZH1 and EZH2 are thought to function in the maintenance of embryonic stem cell pluripotency and plasticity and recently have been shown to be essential for hair follicle homeostasis and wound repair. Overexpression of EZH2 has been reported as a marker for advanced and metastatic cancers. Multiple isoforms of EZH2 are known to exist.Synonyms: ENX-1, Enhancer of zeste homolog 2, Histone-lysine N-methyltransferase EZH2, Lysine N-methyltransferase 6

Gen-ID: 2146

NCBI Accession: NP_001190176

UniProt: Q15910

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation