DYRK2 Antikörper (C-Term)

Produktnummer ABIN783436

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DYRK2 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für DYRK2 Antikörper (C-Term) (ABIN783436)

Target: DYRK2 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DYRK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-DYRK2 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects DYRK2 at C-term. Two isoforms of DYRK2 are known to exist, this antibody will recognize both isoforms. DYRK2 antibody will not cross-react with other DYRK family members.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the carboxy terminus of human DYRK2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu DYRK2

Target: DYRK2 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2))

Andere Bezeichnung: DYRK2

Hintergrund: DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Gen-ID: 8445

NCBI Accession: NP_003574

UniProt: Q92630

Pathways: Regulation of Carbohydrate Metabolic Process