LRRFIP1 Antikörper (C-Term)

Produktnummer ABIN783415

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch LRRFIP1 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für LRRFIP1 Antikörper (C-Term) (ABIN783415)

Target: LRRFIP1 (Leucine Rich Repeat (In FLII) Interacting Protein 1 (LRRFIP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRRFIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-LRRFIP1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects LRRFIP1 at C-term. LRRFIP1 antibody is predicted to not cross-react with other LRRFIP family members. Three isoforms of LRRFIP1 are known to exist, this antibody will only recognize the two longer isoforms.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the carboxy terminus of human LRRFIP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu LRRFIP1

Target: LRRFIP1 (Leucine Rich Repeat (In FLII) Interacting Protein 1 (LRRFIP1))

Andere Bezeichnung: LRRFIP1

Hintergrund: LRRFIP1, also known as GC-binding factor 2 (GCF2), is a 738 amino acid transcriptional repressor that mainly plays a cytoskeletal role. It is primarily localized in the cytoplasm and preferentially binds to GC-rich dsDNA, but will also bind directly to dsRNA as well. The RNA binding domain encompasses a lysine-rich motif. LRRFIP1 interacts with the mammalian Flightless I (Fli-I) and is a key component in the cytoskeletal regulation of platelet function. LRRFIP1 and the related protein LRRFIP2 may modulate canonical WNT signaling and mediate the IRF3-induced production of type I interferon via a B-catenin-dependent pathway.Synonyms: GC-binding factor 2, GCF2, LRR FLII-interacting protein 1, Leucine-rich repeat flightless-interacting protein 1, TAR RNA-interacting protein, TRIP

Gen-ID: 9208

NCBI Accession: NP_001131024

UniProt: Q32MZ4