AXIN2 Antikörper (C-Term)

Produktnummer ABIN783373

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch AXIN2 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für AXIN2 Antikörper (C-Term) (ABIN783373)

Target: AXIN2 (Axin 2 (AXIN2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AXIN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-AXIN2 Antikörper

Bindungsspezifität: C-Term

Spezifität: Thias antibody detects Axin-2 at C-term. It is predicted to not cross-react with AXIN2. At least four isoforms of AXIN2 are known to exist, this antibody will recognize all four.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 20 amino acid peptide near the carboxy terminus of human AXIN2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu AXIN2

Target: AXIN2 (Axin 2 (AXIN2))

Andere Bezeichnung: Axin-2

Hintergrund: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.Synonyms: AXIN2, Axin-like protein, Axis inhibition protein 2, Conductin

Gen-ID: 8313

NCBI Accession: NP_004646

UniProt: Q9Y2T1

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling