This antibody detects ZBTB8 at C-term. At least two isoforms of ZBTB8 are known to exist, this antibody will recognize both isoforms. This antibody is predicted to not cross-react with other ZBTB protein family members.
Species reactivity (tested):Human, mouse
Affinity chromatography purified via peptide column
17 amino acid peptide near the carboxy terminus of human ZBTB8
The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB8, also known as BOZ-F1, is present in multiple tissues, and is highly expressed in the cytoplasm of the placenta. While little is known about ZBTB8, other ZBTB proteins, such as ZBTB4 bind methylated DNA and repress transcription. Another ZBTB proteins, ZBTB7A, has been implicated as a proto-oncogene whose overexpression contributes to malignancy in breast cancer, suggesting that ZBTB8 may act as a transcriptional repressor or be involved in tumorigenesis.Synonyms: BOZ-F1, ZBTB8A, Zinc finger and BTB domain-containing protein 8