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Synaptojanin 1 Antikörper (C-Term)

Der Maus Monoklonal Anti-Synaptojanin 1-Antikörper wurde für WB und IHC (fro) validiert. Er ist geeignet, Synaptojanin 1 in Proben von Ratte zu detektieren.
Produktnummer ABIN782444

Kurzübersicht für Synaptojanin 1 Antikörper (C-Term) (ABIN782444)

Target

Alle Synaptojanin 1 (SYNJ1) Antikörper anzeigen
Synaptojanin 1 (SYNJ1)

Reaktivität

  • 23
  • 19
  • 6
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Ratte

Wirt

  • 33
  • 6
Maus

Klonalität

  • 34
  • 5
Monoklonal

Konjugat

  • 21
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Synaptojanin 1 Antikörper ist unkonjugiert

Applikation

  • 20
  • 14
  • 13
  • 13
  • 7
  • 3
  • 3
  • 3
  • 3
Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon

5H1
  • Bindungsspezifität

    • 15
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    Specific for the ~145k Synaptojanin I protein in Western blots of Rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody. Does not cross react with Mouse.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Rat.

    Aufreinigung

    Protein G Chromatography of Culture Supernatant.

    Immunogen

    Recombinant protein corresponding to amino acid residues from the C-terminal region of Rat Synaptojanin 1.

    Isotyp

    IgG
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store the antibody undiluted (in aliquots) at -20 °C.
  • Target

    Synaptojanin 1 (SYNJ1)

    Andere Bezeichnung

    Synaptojanin-1 / SYNJ1

    Hintergrund

    Synaptojanin is a phosphatidylinositol phosphatase involved in clathrinmediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms, one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down's syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidyl-inositol-4,5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008).Synonyms: 4, 5-trisphosphate 5-phosphatase 1, INPP5G, KIAA0910, Synaptic Marker, Synaptic inositol-1

    Gen-ID

    85238

    NCBI Accession

    NP_445928

    UniProt

    Q62910

    Pathways

    Inositol Metabolic Process, Synaptic Vesicle Exocytosis
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