Synaptojanin 1 Antikörper (C-Term)
Kurzübersicht für Synaptojanin 1 Antikörper (C-Term) (ABIN782444)
Target
Alle Synaptojanin 1 (SYNJ1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- C-Term
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Spezifität
- Specific for the ~145k Synaptojanin I protein in Western blots of Rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody. Does not cross react with Mouse.
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Kreuzreaktivität (Details)
- Species reactivity (tested):Rat.
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Aufreinigung
- Protein G Chromatography of Culture Supernatant.
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Immunogen
- Recombinant protein corresponding to amino acid residues from the C-terminal region of Rat Synaptojanin 1.
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Isotyp
- IgG
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
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Handhabung
- Avoid repeated freezing and thawing.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store the antibody undiluted (in aliquots) at -20 °C.
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- Synaptojanin 1 (SYNJ1)
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Andere Bezeichnung
- Synaptojanin-1 / SYNJ1
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Hintergrund
- Synaptojanin is a phosphatidylinositol phosphatase involved in clathrinmediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms, one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down's syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidyl-inositol-4,5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008).Synonyms: 4, 5-trisphosphate 5-phosphatase 1, INPP5G, KIAA0910, Synaptic Marker, Synaptic inositol-1
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Gen-ID
- 85238
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NCBI Accession
- NP_445928
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UniProt
- Q62910
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Pathways
- Inositol Metabolic Process, Synaptic Vesicle Exocytosis
Target
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