TBC1D4 Antikörper (pSer588)

Produktnummer ABIN8125128

Der Kaninchen Polyklonal anti-TBC1D4 Antikörper wird verwendet zum Nachweis von TBC1D4 in Proben von Human und Maus. Er wurde validiert für WB.

Kurzübersicht für TBC1D4 Antikörper (pSer588) (ABIN8125128)

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBC1D4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TBC1D4 Antikörper

Bindungsspezifität: pSer588

Verwendungszweck: AS160 (Phospho Ser588) Antibody

Spezifität: This antibody detects endogenous levels of Human Mouse AS160 (phospho-Ser588)

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human AS160 (Ser588)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu TBC1D4

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Andere Bezeichnung: AS160

Hintergrund:

Synonyms: TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)

Background: This gene is a member of the Tre-2/BUB2/CDC16 domain family.The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Ph

Gene Name: TBC1D4 AS160 KIAA0603

Protein Name: AS160 (Ser588)

Gen-ID: 9882

UniProt: O60343