STK38L Antikörper (AA 380-460)

Produktnummer ABIN8124614

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch STK38L in WB, ELISA, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für STK38L Antikörper (AA 380-460) (ABIN8124614)

Target: STK38L (serine/threonine Kinase 38 Like (STK38L))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STK38L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-STK38L Antikörper

Bindungsspezifität: AA 380-460

Verwendungszweck: NDR2 Antibody

Spezifität: NDR2 Polyclonal Antibody detects endogenous levels of NDR2 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from NDR2 . at AA range: 380-460

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000.IHC:1:50-300 ELISA: 1:20000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu STK38L

Target: STK38L (serine/threonine Kinase 38 Like (STK38L))

Andere Bezeichnung: NDR2

Hintergrund:

Synonyms: STK38L, KIAA0965, NDR2, Serine/threonine-protein kinase 38-like, NDR2 protein kinase, Nuclear Dbf2-related kinase 2

Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L.,function:Involved in the regulation of structural processes in differentiating and mature neuronal cells.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Associated with the actin cytoskeleton.,subunit:Homodimeric S100B binds two molecules of STK38L (By similarity). Interacts with MOB1 and MOB2.,tissue specificity:Ubiquitously expressed with highest levels observed in the thymus.,

Gene Name: STK38L

Protein Name: Serine/threonine-protein kinase 38-like

Gen-ID: 23012

UniProt: Q9Y2H1