PMS2CL/PMS2 Antikörper (AA 600-700)

Produktnummer ABIN8123821

Der Maus Monoklonal anti-PMS2CL/PMS2 Antikörper (Klon AB2348) (ABIN8123821) detektiert spezifisch PMS2CL/PMS2 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für PMS2CL/PMS2 Antikörper (AA 600-700) (ABIN8123821)

Target: PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PMS2CL/PMS2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: AB2348

Produktdetails anti-PMS2CL/PMS2 Antikörper

Bindungsspezifität: AA 600-700

Verwendungszweck: Postmeiotic Segregation Increased 2 (PMS2) mouse mAb

Spezifität: The antibody can specifically recognize human PMS2 protein.

Aufreinigung: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 600 - 700 of the human Postmeiotic Segregation Increased 2 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC, 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at-20°C. Avoid freeze / thaw cycles.

Details zu PMS2CL/PMS2

Target: PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))

Andere Bezeichnung: Postmeiotic Segregation Increased 2

Hintergrund:

Synonyms: DNA mismatch repair gene homologue, DNA mismatch repair protein PMS2, H_DJ0042M02. 9, HNPCC4, Mismatch repair endonuclease PMS2, Mismatch repair gene PMSL2, MLH4, PMS 2, PMS1 homolog 2 mismatch repair system, PMS1 protein homolog 2, PMS2, PMS2 postmeiotic segregation increased 2, PMS2 postmeiotic segregation increased 2 (S. cerevisiae) , PMS2_HUMAN, PMS2CL, PMSL2, Postmeiotic segregation increased, S. cerevisiae, 2

Background: Human mismatch repair genes play an important role in maintaining the integrity and stability of genetic information and avoiding genetic mutation. PMS2 is a mismatch repair protein with a molecular weight of 96 kDa, located on chromosome 7. It mainly corrects single base mismatch and small fragment mismatch in vivo. PMS2 forms heterodimer with MLH1 protein and coordinates the binding of other proteins after being activated by ATP to repair DNA errors during cell division. At present, it is mostly used for Lynch syndrome screening together with MLH1, MSH2 and MSH6.

Gene Name: PMS2

Protein Name: Postmeiotic Segregation Increased 2

Gen-ID: 5395

UniProt: P54278