NPLOC4 Antikörper (AA 270-350)

Produktnummer ABIN8123420

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NPLOC4 in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für NPLOC4 Antikörper (AA 270-350) (ABIN8123420)

Target: NPLOC4 (Nuclear Protein Localization 4 Homolog (NPLOC4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPLOC4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-NPLOC4 Antikörper

Bindungsspezifität: AA 270-350

Verwendungszweck: NPL4 Antibody

Spezifität: NPL4 Polyclonal Antibody detects endogenous levels of protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 270-350

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000 ELISA 1:5000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu NPLOC4

Target: NPLOC4 (Nuclear Protein Localization 4 Homolog (NPLOC4))

Andere Bezeichnung: NPL4

Hintergrund:

Background: domain:Binds ubiquitinated proteins via its RanBP2-type zinc finger.,function:The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.,pathway:Protein degradation, proteasomal ubiquitin-dependent pathway.,similarity:Belongs to the NPL4 family.,similarity:Contains 1 RanBP2-type zinc finger.,subcellular location:Associated with the endoplasmic reticulum and nuclear.,subunit:Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion.,tissue specificity:Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.,

Gene Name: NPLOC4 KIAA1499 NPL4

Protein Name: Nuclear protein localization protein 4 homolog (Protein NPL4)

Gen-ID: 55666

UniProt: Q8TAT6