MMP19 Antikörper (Cleaved-Tyr98)

Produktnummer ABIN8122797

Der Kaninchen Polyklonal anti-MMP19 Antikörper wird verwendet zum Nachweis von MMP19 in Proben von Human und Maus. Er wurde validiert für WB und IHC.

Kurzübersicht für MMP19 Antikörper (Cleaved-Tyr98) (ABIN8122797)

Target: MMP19 (Matrix Metallopeptidase 19 (MMP19))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP19 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-MMP19 Antikörper

Bindungsspezifität: Cleaved-Tyr98

Verwendungszweck: MMP19 (Cleaved-Tyr98) Antibody

Spezifität: This antibody detects endogenous levels of Human,Mouse MMP19 (Cleaved-Tyr98, protein was cleaved amino acid sequence between 97-98 )

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human MMP19 (Cleaved-Tyr98)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000,IHC 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu MMP19

Target: MMP19 (Matrix Metallopeptidase 19 (MMP19))

Andere Bezeichnung: MMP19

Hintergrund:

Synonyms: Matrix metalloproteinase-19 (MMP-19, EC 3.4.24.-, Matrix metalloproteinase RASI, Matrix metalloproteinase-18, MMP-18)

Background: alternative products:Additional isoforms seem to exist,catalytic activity:Cleaves aggrecan at the 360-Ser-|-Phe-361 site.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,disease:May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Strongly inhibited by TIMP-2, TIMP-3 and TIMP-4, while TIMP-1 is less efficient.,function:Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.,PTM:Activated by autolytic cleavage after Lys-97.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.,

Gene Name: MMP19 MMP18 RASI

Protein Name: MMP19 (Cleaved-Tyr98)

Gen-ID: 4327

UniProt: Q99542