Glutathione Peroxidase 2 Antikörper (AA 113-163)

Produktnummer ABIN8121709

Der Kaninchen Polyklonal anti-Glutathione Peroxidase 2 Antikörper (ABIN8121709) detektiert spezifisch Glutathione Peroxidase 2 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Glutathione Peroxidase 2 Antikörper (AA 113-163) (ABIN8121709)

Target: Glutathione Peroxidase 2 (GPX2)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutathione Peroxidase 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Glutathione Peroxidase 2 Antikörper

Bindungsspezifität: AA 113-163

Verwendungszweck: GPX2 Antibody

Spezifität: This antibody detects endogenous levels of GPX2 at Human/Mouse/Rat

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human GPX2 AA range: 113-163

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Glutathione Peroxidase 2

Target: Glutathione Peroxidase 2 (GPX2)

Andere Bezeichnung: GPX2

Hintergrund:

Background: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016],

Gene Name: GPX2

Protein Name: GPX2

Gen-ID: 2877

UniProt: P18283

Pathways: Thyroid Hormone Synthesis