FGD4 Antikörper (AA 291-341)

Produktnummer ABIN8121549

Der Kaninchen Polyklonal anti-FGD4 Antikörper wird verwendet zum Nachweis von FGD4 in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für FGD4 Antikörper (AA 291-341) (ABIN8121549)

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGD4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FGD4 Antikörper

Bindungsspezifität: AA 291-341

Verwendungszweck: FGD4 Antibody

Spezifität: This antibody detects endogenous levels of FGD4 at Human/Mouse/Rat

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human FGD4 AA range: 291-341

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu FGD4

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Andere Bezeichnung: FGD4

Hintergrund:

Synonyms: FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6)

Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],

Gene Name: FGD4 FRABP ZFYVE6

Protein Name: FGD4

Gen-ID: 121512

UniProt: Q96M96

Pathways: Neurotrophin Signalübertragung