DCLK1 Antikörper (AA 514-564)

Produktnummer ABIN8121064

Der Kaninchen Polyklonal anti-DCLK1 Antikörper (ABIN8121064) detektiert spezifisch DCLK1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für DCLK1 Antikörper (AA 514-564) (ABIN8121064)

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCLK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DCLK1 Antikörper

Bindungsspezifität: AA 514-564

Verwendungszweck: DCLK1 Antibody

Spezifität: This antibody detects endogenous levels of DCLK1 at Human/Mouse/Rat

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human DCLK1 AA range: 514-564

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu DCLK1

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Andere Bezeichnung: DCLK1

Hintergrund:

Background: This gene encodes a member of the protein kinase superfamily and the doublecortin family.The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010],

Gene Name: DCLK1 DCAMKL1 DCDC3A KIAA0369

Protein Name: DCLK1

Gen-ID: 9201

UniProt: O15075