Doublecortin Antikörper (pSer378)

Produktnummer ABIN8121061

Der Kaninchen Polyklonal anti-Doublecortin Antikörper (ABIN8121061) detektiert spezifisch Doublecortin in WB, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Doublecortin Antikörper (pSer378) (ABIN8121061)

Target: Doublecortin (DCX)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Doublecortin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Doublecortin Antikörper

Bindungsspezifität: pSer378

Verwendungszweck: Doublecortin (Phospho Ser378) Antibody

Spezifität: This antibody detects endogenous phospho levels of Doublecortin (Phospho-Ser378) at Human:S378, Mouse:S297, Rat:S297

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human Doublecortin (Phospho-Ser378)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-200, WB 1:500-2000. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Doublecortin

Target: Doublecortin (DCX)

Andere Bezeichnung: Doublecortin

Hintergrund:

Synonyms: Neuronal migration protein doublecortin (Doublin; Lissencephalin-X; Lis-X)

Background: This gene encodes a member of the doublecortin family.The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain&quo

Gene Name: DCX DBCN LISX

Protein Name: Doublecortin (Phospho-Ser378)

Gen-ID: 1641

UniProt: O43602