Exportin 2 Antikörper (AA 1-100)

Produktnummer ABIN8120761

Der Maus Monoklonal anti-Exportin 2 Antikörper (Klon AB2423) (ABIN8120761) detektiert spezifisch Exportin 2 in WB, IF und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Exportin 2 Antikörper (AA 1-100) (ABIN8120761)

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Exportin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA

Klon: AB2423

Produktdetails anti-Exportin 2 Antikörper

Bindungsspezifität: AA 1-100

Verwendungszweck: Cellular Apoptosis Susceptibility/CSE1L mouse mAb

Spezifität: This antibody detects endogenous levels of CSE1L.

Aufreinigung: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 1 - 100 of the human Cellular Apoptosis Susceptibility/CSE1L protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at-20°C. Avoid freeze / thaw cycles.

Details zu Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Andere Bezeichnung: Cellular Apoptosis Susceptibility/CSE1L

Hintergrund:

Synonyms: CSE1L,CAS,XPO2,Exportin-2,Exp2,Cellular apoptosis susceptibility protein,Chromosome segregation 1-like protein,Importin-alpha re-exporter

Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012],

Gene Name: CSE1L

Protein Name: Cellular Apoptosis Susceptibility/CSE1L

Gen-ID: 1434

UniProt: P55060

Pathways: Protein targeting to Nucleus