CRTC2 Antikörper (pSer171)

Produktnummer ABIN8120753

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CRTC2 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für CRTC2 Antikörper (pSer171) (ABIN8120753)

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRTC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CRTC2 Antikörper

Bindungsspezifität: pSer171

Verwendungszweck: TORC2 (phospho Ser171) Antibody

Spezifität: This antibody detects endogenous levels of TORC2 Phospho-Ser171 at Human, Mouse,Rat

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human TORC2 Phospho-Ser171

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu CRTC2

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Andere Bezeichnung: TORC2

Hintergrund:

Synonyms: CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)

Background: This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010],

Gene Name: CRTC2 TORC2

Protein Name: TORC2 Phospho-Ser171

Gen-ID: 200186

UniProt: Q53ET0

Pathways: AMPK Signaling, Carbohydrate Homeostasis