Caspase-8 p18 Antikörper (Cleaved-Ser217)

Produktnummer ABIN8120241

Der Kaninchen Polyklonal anti-Caspase-8 p18 Antikörper wird verwendet zum Nachweis von Caspase-8 p18 in Proben von Human. Er wurde validiert für WB und ELISA.

Kurzübersicht für Caspase-8 p18 Antikörper (Cleaved-Ser217) (ABIN8120241)

Target: Caspase-8 p18 (Caspase 8 Subunit P18)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase-8 p18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Caspase-8 p18 Antikörper

Bindungsspezifität: AA 170-250, Cleaved-Ser217

Verwendungszweck: Cleaved-Caspase-8 p18 (S217) Antibody

Spezifität: Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody detects endogenous levels of Cleaved-Caspase-8 p18 (S217) protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Cleaved-Caspase-8 p18 (S217) . at AA range: 170-250

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Caspase-8 p18

Target: Caspase-8 p18 (Caspase 8 Subunit P18)

Andere Bezeichnung: Caspase-8 p18

Hintergrund:

Synonyms: CASP8, MCH5, Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alt

Gene Name: CASP8

Protein Name: Caspase8

Gen-ID: 841

UniProt: Q14790