BMP4 Antikörper (AA 261-310)

Produktnummer ABIN8120011

Der Kaninchen Polyklonal anti-BMP4 Antikörper (ABIN8120011) detektiert spezifisch BMP4 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für BMP4 Antikörper (AA 261-310) (ABIN8120011)

Target: BMP4 (Bone Morphogenetic Protein 4 (BMP4))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BMP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-BMP4 Antikörper

Bindungsspezifität: AA 261-310

Verwendungszweck: BMP-4 Antibody

Spezifität: This antibody detects endogenous levels of Human BMP-4

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human BMP-4 AA range: 261-310

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-2000 ELISA 1:5000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu BMP4

Target: BMP4 (Bone Morphogenetic Protein 4 (BMP4))

Andere Bezeichnung: BMP-4

Hintergrund:

Synonyms: Bone morphogenetic protein 4 (BMP-4, Bone morphogenetic protein 2B, BMP-2B)

Background: disease:Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6) [MIM:607932], also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies.,function:Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair.,online information:Bone morphogenetic protein 4 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer, disulfide-linked (By similarity). Interacts with GREM2 (By similarity) and SOSTDC1. Part of a complex consisting of TWSG1 and CHRD.,tissue specificity:Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.,

Gene Name: BMP4 BMP2B DVR4

Protein Name: BMP-4

Gen-ID: 652

UniProt: P12644

Pathways: Steroid Hormone Mediated Signaling Pathway, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development