KSR2 Antikörper (N-Term)

Produktnummer ABIN8103917

Der Kaninchen Polyklonal anti-KSR2 Antikörper wird verwendet zum Nachweis von KSR2 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für KSR2 Antikörper (N-Term) (ABIN8103917)

Target: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KSR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KSR2 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: KSR2 Antibody - N-terminal region

Sequenz: LQQCELVQNM IDLSISNLEG LRTKCATSND LTQKEIRTLE SKLVKYFSRQ

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human KSR2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP62199-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu KSR2

Target: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Andere Bezeichnung: KSR2

Hintergrund:

Background Information: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Gene Name: kinase suppressor of ras 2

Protein Name: Kinase suppressor of Ras 2

Molekulargewicht: 108 kDa

Gen-ID: 283455

UniProt: Q6VAB6