APOBEC3A Antikörper (C-Term)

Produktnummer ABIN8094802

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch APOBEC3A in WB. Es zeigt Reaktivität gegenüber Proben von Human und Schwein.

Kurzübersicht für APOBEC3A Antikörper (C-Term) (ABIN8094802)

Target: APOBEC3A (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))

Reaktivität: Human, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APOBEC3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-APOBEC3A Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: APOBEC3A Antibody - C-terminal region

Sequenz: AQVSIMTYDE FKHCWDTFVD HQGCPFQPWD GLDEHSQALS GRLRAILQNQ

Homologie: Human: 100%, Pig: 100%

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ABC3A

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61579-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu APOBEC3A

Target: APOBEC3A (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))

Andere Bezeichnung: APOBEC3A

Hintergrund:

Background Information: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B.

Gene Name: APOBEC3A and APOBEC3B deletion hybrid

Alternative Symbols: A3A, APOBEC3A

Protein Name: probable DNA dC->dU-editing enzyme APOBEC-3A

Molekulargewicht: 21kDa

Gen-ID: 100913187

NCBI Accession: XP_005277017

UniProt: P31941