TFPI2 Antikörper (AA 100-235)

Produktnummer ABIN8093520

Der Maus Monoklonal anti-TFPI2 Antikörper (Klon TFPI2-13028) (ABIN8093520) detektiert spezifisch TFPI2 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TFPI2 Antikörper (AA 100-235) (ABIN8093520)

Target: TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TFPI2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: TFPI2-13028

Produktdetails anti-TFPI2 Antikörper

Bindungsspezifität: AA 100-235

Verwendungszweck: TFPI2 Antibody / Tissue factor pathway inhibitor 2

Immunogen: A recombinant fragment (around amino acids 100-235) of human TFPI2 protein (exact sequence is proprietary) was used as the immunogen for the Placental Protein 5/TFPI2 antibody.

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Placental Protein 5/TFPI2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Placental Protein 5/TFPI2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu TFPI2

Target: TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))

Andere Bezeichnung: TFPI2

Hintergrund: Placental Protein 5 antibody, also known as TFPI2 antibody, recognizes Placental Protein 5, the historical name for Tissue factor pathway inhibitor 2 encoded by the TFPI2 gene. Originally identified in placental tissue, Placental Protein 5 is a secreted Kunitz-type serine protease inhibitor that associates with the extracellular matrix and regulates pericellular proteolysis. The protein contains three tandem Kunitz domains that enable inhibition of multiple serine proteases involved in matrix degradation and tissue remodeling. Placental Protein 5 antibody is widely used in research examining extracellular matrix regulation, trophoblastic biology, and tumor invasion mechanisms.

TFPI2 is synthesized with a signal peptide and secreted into the extracellular environment, where it binds matrix components and modulates local protease activity. Although structurally related to Tissue factor pathway inhibitor 1, Placental Protein 5 primarily functions in extracellular matrix homeostasis rather than directly regulating the tissue factor coagulation cascade. By inhibiting proteases such as plasmin and trypsin-like enzymes, TFPI2 contributes to maintaining tissue integrity and limiting excessive matrix breakdown. Reduced TFPI2 expression has been reported in various malignancies, often associated with promoter hypermethylation and increased invasive potential.

Expression of Placental Protein 5 has been documented in placenta, vascular endothelium, and selected epithelial tissues. In placental tissue, extracellular and pericellular localization patterns are consistent with its matrix-associated inhibitory role. In cancer biology studies, TFPI2 antibody is frequently used to evaluate epigenetic silencing, stromal interactions, and tumor microenvironment remodeling. Clone TFPI2/13028 is designed to detect Placental Protein 5 in research applications and supports investigation of extracellular protease regulation and matrix-associated signaling pathways.

UniProt: P48307