PRND Antikörper (AA 111-144)

Produktnummer ABIN8093424

Der Kaninchen Polyklonal anti-PRND Antikörper (ABIN8093424) detektiert spezifisch PRND in WB, ELISA, IHC, IF und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für PRND Antikörper (AA 111-144) (ABIN8093424)

Target: PRND (Prion Protein 2 (Dublet) (PRND))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRND Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-PRND Antikörper

Bindungsspezifität: AA 111-144

Verwendungszweck: PRND Antibody / Prion-like protein doppel

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human Prion-like protein doppel recombinant protein (amino acids A111-H144) was used as the immunogen for the PRND antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PRND antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PRND antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PRND

Target: PRND (Prion Protein 2 (Dublet) (PRND))

Andere Bezeichnung: PRND

Hintergrund: PRND antibody targets Prion-like protein doppel, encoded by the PRND gene. Prion-like protein doppel is a glycosylphosphatidylinositol-anchored protein that shares structural similarity with the cellular prion protein, although it exhibits distinct expression patterns and biological functions. PRND is primarily localized to the cell surface, where it associates with lipid rafts and extracellular environments. Unlike the ubiquitously expressed prion protein, doppel expression is more restricted and shows strong tissue specificity.

Functionally, Prion-like protein doppel has been implicated in regulation of cell survival, differentiation, and tissue homeostasis. PRND is particularly associated with male reproductive biology, where it plays an important role in spermatogenesis and sperm function. Loss or dysregulation of PRND expression has been linked to impaired fertility, highlighting its physiological importance. A PRND antibody supports studies focused on reproductive biology and prion-related protein function.

PRND expression is most prominent in testicular tissue, with lower or tightly regulated expression reported in other tissues. Its membrane localization and glycosylation state contribute to its functional interactions with extracellular partners and signaling pathways. Because of its restricted expression profile, PRND is often used as a marker for studying tissue-specific regulation and differentiation states in reproductive systems.

From a disease-relevance perspective, Prion-like protein doppel has been investigated in the context of neurobiology and cancer. Aberrant expression of PRND has been reported in certain tumor types, where it may influence cell survival and tumor progression. In addition, due to its structural relationship with prion proteins, PRND is of interest in studies examining prion biology and protein misfolding mechanisms, although it is not itself associated with transmissible prion diseases.

At the molecular level, Prion-like protein doppel contains conserved domains involved in protein folding and membrane attachment through its GPI anchor. Post-translational modifications, including glycosylation, can influence its apparent molecular weight and behavior in biochemical assays without altering the primary amino acid sequence. PRND antibody reagents support research applications focused on reproductive biology, prion-related proteins, and disease-associated expression changes, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q9UKY0

Pathways: Transition Metal Ion Homeostasis