PDSS2 Antikörper (C-Term)

Produktnummer ABIN8093423

Der Kaninchen Polyklonal anti-PDSS2 Antikörper wird verwendet zum Nachweis von PDSS2 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für PDSS2 Antikörper (C-Term) (ABIN8093423)

Target: PDSS2 (Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 2 (PDSS2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDSS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PDSS2 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: PDSS2 Antibody / Prenyl diphosphate synthase subunit 2

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Prenyl diphosphate synthase subunit 2 was used as the immunogen for the PDSS2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PDSS2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PDSS2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PDSS2

Target: PDSS2 (Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 2 (PDSS2))

Andere Bezeichnung: PDSS2

Hintergrund: PDSS2 antibody targets Prenyl diphosphate synthase subunit 2, encoded by the PDSS2 gene. Prenyl diphosphate synthase subunit 2 is a mitochondrial protein that functions as a core component of the decaprenyl diphosphate synthase complex, which is required for coenzyme Q (ubiquinone) biosynthesis. This enzyme complex catalyzes the elongation of polyprenyl chains that form the hydrophobic tail of coenzyme Q, a critical molecule for mitochondrial electron transport and cellular energy production.

Prenyl diphosphate synthase subunit 2 acts in concert with PDSS1 to regulate the length and synthesis of decaprenyl diphosphate, a key intermediate in ubiquinone production. Through this role, PDSS2 indirectly supports mitochondrial respiratory chain function, redox balance, and ATP generation. A PDSS2 antibody supports studies focused on mitochondrial metabolism, prenyltransferase activity, and coenzyme Q biosynthetic pathways.

PDSS2 is predominantly localized to mitochondria, consistent with its role in energy metabolism and oxidative phosphorylation. Expression has been observed in metabolically active tissues, where efficient coenzyme Q production is essential for maintaining respiratory capacity. Alterations in PDSS2 expression or function can disrupt mitochondrial electron transport efficiency and increase susceptibility to oxidative stress, highlighting its importance in cellular homeostasis.

From a disease relevance perspective, Prenyl diphosphate synthase subunit 2 has been implicated in mitochondrial disorders and kidney-related pathologies, including steroid-resistant nephrotic syndrome, where impaired coenzyme Q biosynthesis contributes to cellular dysfunction. Reduced PDSS2 activity has also been explored in cancer biology, where changes in mitochondrial metabolism and redox control influence tumor cell behavior and survival.

At the molecular level, Prenyl diphosphate synthase subunit 2 contains conserved prenyltransferase-associated domains that support isoprenoid chain elongation within the mitochondrial matrix. Its enzymatic activity and stability may be influenced by mitochondrial context and metabolic state, which can affect apparent behavior in biochemical assays. PDSS2 antibody reagents enable investigation of mitochondrial coenzyme Q biosynthesis and metabolic regulation, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q86YH6