PDE4A Antikörper (N-Term)

Produktnummer ABIN8093407

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PDE4A in IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PDE4A Antikörper (N-Term) (ABIN8093407)

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE4A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-PDE4A Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: PDE4A Antibody / cAMP-specific 3,5-cyclic phosphodiesterase 4A

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Phosphodiesterase 4A was used as the immunogen for the PDE4A antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PDE4A antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PDE4A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PDE4A

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Andere Bezeichnung: PDE4A

Hintergrund: PDE4A antibody targets Phosphodiesterase 4A, encoded by the PDE4A gene. Phosphodiesterase 4A is a member of the phosphodiesterase 4 family of enzymes that specifically hydrolyze cyclic adenosine monophosphate (cAMP), a key second messenger involved in intracellular signaling. PDE4A is predominantly localized to the cytoplasm and associates with signaling complexes that spatially restrict cAMP degradation within cells.

Functionally, Phosphodiesterase 4A regulates the amplitude and duration of cAMP-dependent signaling pathways by controlling intracellular cAMP concentrations. Through this activity, PDE4A influences protein kinase A activation and downstream transcriptional and metabolic responses. A PDE4A antibody supports studies focused on cAMP signaling, signal compartmentalization, and regulation of second messenger dynamics.

PDE4A is expressed in multiple tissues and cell types, with particularly important roles in immune cells, neuronal tissues, and inflammatory environments. Its expression pattern reflects the widespread reliance on cAMP signaling for regulation of immune responses, neurotransmission, and cellular homeostasis. PDE4A often functions as part of multiprotein signaling assemblies, allowing precise local control of cAMP levels.

From a disease-relevance perspective, Phosphodiesterase 4A has been investigated in inflammatory disorders, neuropsychiatric conditions, and cancer. Dysregulated PDE4A activity can lead to abnormal cAMP signaling, contributing to altered immune activation, impaired neuronal signaling, and changes in cell proliferation. As a result, PDE4A and related family members are considered important targets in studies of inflammation and signal transduction.

At the molecular level, Phosphodiesterase 4A contains conserved catalytic domains responsible for cAMP hydrolysis, along with regulatory regions that mediate protein-protein interactions and subcellular targeting. Alternative splicing and post-translational regulation can influence its apparent behavior in biochemical assays without altering the primary amino acid sequence. PDE4A antibody reagents support research applications focused on second messenger signaling and disease-associated alterations in cAMP regulation, with NSJ Bioreagents providing reagents intended for research use.

UniProt: P27815

Pathways: cAMP Metabolic Process