Rekombinanter Peripherin Antikörper (full length)

Produktnummer ABIN8093402

Der Maus Monoklonal anti-Peripherin Antikörper wird verwendet zum Nachweis von Peripherin in Proben von Human. Er wurde validiert für WB und IHC.

Kurzübersicht für Rekombinanter Peripherin Antikörper (full length) (ABIN8093402)

Target: Peripherin (PRPH)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Peripherin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: RPJM50

Produktdetails anti-Peripherin Antikörper

Bindungsspezifität: full length

Verwendungszweck: PRPH Antibody / Peripherin

Immunogen: Prokaryotic recombinant protein corresponding to the full-length peripherin molecule was used as the immunogen for the PRPH/Peripherin antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: 1. Optimal dilution of the PRPH/Peripherin antibody should be determined by the researcher.

2. This PRPH/Peripherin antibody is recombinantly produced by expression in CHO cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: PRPH/Peripherin antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu Peripherin

Target: Peripherin (PRPH)

Andere Bezeichnung: PRPH

Hintergrund: PRPH antibody, also known as Peripherin antibody, recognizes Peripherin, a type III intermediate filament protein encoded by the PRPH gene and primarily expressed in neurons of the peripheral nervous system. Peripherin is localized to the cytoplasm, where it assembles into intermediate filament networks that support neuronal structure and axonal integrity. PRPH expression is enriched in peripheral sensory and autonomic neurons and is also detected in certain central nervous system neurons during development and regeneration. As a neuronal cytoskeletal protein, Peripherin plays a critical role in maintaining axonal architecture and structural stability.

PRPH antibody detects a protein composed of a conserved alpha-helical rod domain flanked by non-helical head and tail domains, characteristic of intermediate filament family members. Peripherin can form homopolymers or heteropolymers with other neuronal intermediate filament proteins, including neurofilament light chain, contributing to regulation of axonal caliber and cytoskeletal organization. Expression of Peripherin is developmentally regulated and is often upregulated following neuronal injury, linking PRPH to nerve regeneration and repair processes.

Functionally, Peripherin is involved in neurite outgrowth, axonal elongation, and cytoskeletal remodeling. It is widely used as a marker of peripheral nerve fibers in research applications and is particularly associated with small diameter sensory neurons. Altered PRPH expression or abnormal accumulation of Peripherin has been reported in neurodegenerative conditions, including models of amyotrophic lateral sclerosis, where cytoskeletal dysregulation may contribute to motor neuron pathology. These findings highlight the importance of Peripherin in neuronal maintenance and disease-associated structural changes.

The PRPH gene is located on chromosome 12 and is transcriptionally regulated during neuronal differentiation and stress responses. Because of its selective neuronal expression pattern and involvement in cytoskeletal dynamics, detection of PRPH protein provides insight into peripheral nerve biology, neuronal development, and regeneration mechanisms.

This recombinant monoclonal PRPH antibody (clone rPJM50) targets Peripherin protein in research applications. PRPH antibody supports investigation of neuronal cytoskeletal organization, axonal growth, injury response, and neurodegenerative disease models.

UniProt: P41219