MUC4 Antikörper (AA 1730-1864)

Produktnummer ABIN8093343

Der Maus Monoklonal anti-MUC4 Antikörper (Klon MUC4-2863) (ABIN8093343) detektiert spezifisch MUC4 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MUC4 Antikörper (AA 1730-1864) (ABIN8093343)

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MUC4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Klon: MUC4-2863

Produktdetails anti-MUC4 Antikörper

Bindungsspezifität: AA 1730-1864

Verwendungszweck: MUC4 Antibody / Mucin 4 (azide and preservative free)

Immunogen: A recombinant fragment (around amino acids 1730-1864) of human MUC4 protein (exact sequence is proprietary) was used as the immunogen for the ASGP-2/MUC4 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ASGP-2/MUC4 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: ASGP-2/MUC4 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu MUC4

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Andere Bezeichnung: MUC4

Hintergrund: ASGP-2 antibody targets Mucin-4, a large transmembrane glycoprotein encoded by the human MUC4 gene and a member of the membrane-bound mucin family. ASGP-2, short for Ascites sialoglycoprotein 2, represents the membrane-associated subunit of the MUC4 heterodimer that was originally characterized in ascites tumor cells. In the literature, ASGP-2 antibody and MUC4 antibody are used interchangeably because ASGP-2 corresponds to the membrane-bound component of Mucin-4. This historical nomenclature remains relevant in cancer biology and epithelial differentiation studies.

MUC4 is synthesized as a high molecular weight precursor that undergoes proteolytic processing into two subunits, commonly referred to as ASGP-1 and ASGP-2, which remain non-covalently associated at the cell surface. The extracellular domain contains heavily O-glycosylated tandem repeat regions that contribute to mucosal barrier function. In normal tissues, Mucin-4 expression is primarily localized to glandular and ductal epithelial cells of the respiratory, gastrointestinal, and genitourinary tracts. During malignant transformation, MUC4 expression frequently becomes upregulated and loses apical polarity, contributing to altered cell adhesion, enhanced tumor cell survival, and increased metastatic potential. ASGP-2 antibody is therefore valuable for evaluating epithelial tumor progression and differentiation status.

Mucin-4 has been shown to interact with receptor tyrosine kinases such as ERBB2, modulating downstream signaling pathways involved in proliferation and resistance to apoptosis. Elevated MUC4 expression has been documented in pancreatic, breast, lung, ovarian, gastric, and colorectal carcinomas, where it may correlate with aggressive disease and poor clinical outcome. ASGP-2 antibody supports investigations into these oncogenic signaling mechanisms and tumor-associated expression patterns.

Structurally, the ASGP-2 subunit contains epidermal growth factor-like domains, a transmembrane region, and a cytoplasmic tail involved in signal transduction. An ASGP-2 antibody such as clone MUC4/2863 is suitable for detecting MUC4 expression in epithelial tissues and carcinoma research applications.

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity