CDH6 Antikörper (AA 250-450)

Produktnummer ABIN8093274

Der Maus Monoklonal anti-CDH6 Antikörper (Klon CDH6-9347) (ABIN8093274) detektiert spezifisch CDH6 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für CDH6 Antikörper (AA 250-450) (ABIN8093274)

Target: CDH6 (K-Cadherin (CDH6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CDH6 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: CDH6-9347

Produktdetails anti-CDH6 Antikörper

Bindungsspezifität: AA 250-450

Verwendungszweck: CDH6 Antibody / Cadherin 6

Immunogen: A recombinant fragment (around amino acids 250-450) of human Cadherin 6 protein (CDH6) (exact sequence is proprietary) was used as the immunogen for the CDH6/Cadherin 6 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CDH6/Cadherin 6 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: CDH6/Cadherin 6 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu CDH6

Target: CDH6 (K-Cadherin (CDH6))

Andere Bezeichnung: CDH6

Hintergrund: CDH6 antibody targets Cadherin 6, also known as K-Cadherin, a calcium-dependent cell-cell adhesion molecule encoded by the CDH6 gene and a member of the classical cadherin family. Cadherin 6 is a single-pass transmembrane glycoprotein predominantly localized to the plasma membrane at adherens junctions, where it mediates homophilic adhesion between neighboring cells. CDH6 expression is most prominent in renal epithelium, nervous system tissues, and select epithelial compartments, reflecting its role in tissue organization and morphogenesis.

Functionally, Cadherin 6 contributes to epithelial cohesion and structural integrity by linking adjacent cells through calcium-dependent interactions and coupling to the actin cytoskeleton via catenin complexes. A short functional summary is that CDH6 supports stable cell-cell adhesion required for proper epithelial architecture and differentiation. Through these adhesive functions, K-Cadherin influences cell polarity, migration, and tissue patterning during development.

At the molecular level, Cadherin 6 contains multiple extracellular cadherin repeat domains responsible for calcium binding and adhesive specificity, a transmembrane region, and a conserved cytoplasmic tail that interacts with beta-catenin and related adaptor proteins. These structural features integrate extracellular adhesion with intracellular signaling pathways. CDH6 antibody reagents are therefore valuable for studying adherens junction biology, epithelial development, and regulation of cell-cell contacts. Clone CDH6/9347 is designed to recognize Cadherin 6 and supports consistent detection of CDH6 expression in research applications.

From a biological and disease relevance perspective, altered Cadherin 6 expression has been reported in several cancers, including renal, ovarian, and thyroid carcinomas, where changes in CDH6 levels may be associated with tumor progression and invasive behavior. Cadherin 6 is also investigated in developmental biology due to its regulated expression during organogenesis. Clone CDH6/9347 provides a reliable reagent for examining Cadherin 6 expression in studies of epithelial differentiation, cancer biology, and cell adhesion dynamics.

Developmentally, CDH6 expression is tightly regulated and contributes to tissue-specific patterning and morphogenetic processes. CDH6 antibodies from NSJ Bioreagents are supplied for research use to support investigations in epithelial biology, development, and translational research.

UniProt: P55285

Pathways: Cell-Cell Junction Organization