HSD17B13 Antikörper (AA 1-200)

Produktnummer ABIN8093248

Dieser Maus Monoklonal Antikörper detektiert spezifisch HSD17B13 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für HSD17B13 Antikörper (AA 1-200) (ABIN8093248)

Target: HSD17B13 (Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HSD17B13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: HSD17B13-13105

Produktdetails anti-HSD17B13 Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: HSD17B13 Antibody / Hydroxysteroid 17 beta dehydrogenase 13

Immunogen: A recombinant fragment (around amino acids 1-200) of human HSD17B13 protein (exact sequence is proprietary) was used as the immunogen for the HSD17B13/Hydroxysteroid 17 beta dehydrogenase 13 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the HSD17B13/Hydroxysteroid 17 beta dehydrogenase 13 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: HSD17B13/Hydroxysteroid 17 beta dehydrogenase 13 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu HSD17B13

Target: HSD17B13 (Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13))

Andere Bezeichnung: HSD17B13

Hintergrund: HSD17B13 antibody targets Hydroxysteroid 17 beta dehydrogenase 13, a liver-enriched enzyme encoded by the HSD17B13 gene that belongs to the hydroxysteroid dehydrogenase family. Hydroxysteroid 17 beta dehydrogenase 13 is predominantly localized to the cytoplasm and lipid droplet-associated compartments of hepatocytes, where it participates in hepatic lipid metabolism and steroid-related redox processes. Because of its strong liver specificity, an HSD17B13 antibody is widely used in studies of liver biology and metabolic disease.

Hydroxysteroid 17 beta dehydrogenase 13 is structurally related to other 17 beta-hydroxysteroid dehydrogenases but displays distinct substrate specificity and tissue distribution. It contains a conserved short-chain dehydrogenase reductase domain, supporting enzymatic activity linked to lipid and steroid metabolism. In hepatocytes, HSD17B13 associates with lipid droplets and is thought to modulate lipid storage and turnover, making antibody-based detection valuable for investigating hepatocellular metabolic regulation.

Genetic studies have identified HSD17B13 as a key modifier of liver disease risk. Specific loss-of-function variants in the HSD17B13 gene are associated with protection against non-alcoholic fatty liver disease, steatohepatitis, and progression to cirrhosis. Conversely, altered expression of Hydroxysteroid 17 beta dehydrogenase 13 has been reported in fatty liver disease and hepatocellular carcinoma. Use of an HSD17B13 antibody enables analysis of protein expression patterns linked to liver pathology and disease susceptibility.

Hydroxysteroid 17 beta dehydrogenase 13 expression is largely restricted to liver tissue, with minimal expression detected in most extrahepatic tissues. This restricted distribution makes HSD17B13 a useful marker for hepatocyte identity and liver-specific metabolic states. An HSD17B13 antibody can therefore support studies of hepatic differentiation, liver injury, and metabolic remodeling.

Clone HSD17B13/13105 is designed to recognize Hydroxysteroid 17 beta dehydrogenase 13 and supports detection of HSD17B13 expression in research applications. NSJ Bioreagents offers this HSD17B13 antibody to support investigations into liver metabolism, fatty liver disease, and hepatocellular biology.

UniProt: Q7Z5P4