HNF1B Antikörper (AA 1-200)

Produktnummer ABIN8093247

Der Maus Monoklonal anti-HNF1B Antikörper (Klon HNF1B-9519) (ABIN8093247) detektiert spezifisch HNF1B in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für HNF1B Antikörper (AA 1-200) (ABIN8093247)

Target: HNF1B (HNF1 Homeobox B (HNF1B))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HNF1B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Klon: HNF1B-9519

Produktdetails anti-HNF1B Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: HNF1B Antibody / Transcription factor HNF1 beta (azide and preservative free)

Immunogen: A recombinant fragment (around amino acids 1-200) of human HNF1B protein (exact sequence is proprietary) was used as the immunogen for the TCF2/HNF1B antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TCF2/HNF1B antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: TCF2/HNF1B antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu HNF1B

Target: HNF1B (HNF1 Homeobox B (HNF1B))

Andere Bezeichnung: HNF1B

Hintergrund: TCF2 antibody, also known as Hepatocyte nuclear factor 1 beta antibody, recognizes a homeodomain-containing transcription factor encoded by the HNF1B gene. This protein is commonly referred to as HNF1 beta and was historically described as TCF2 in early genetic studies. HNF1B is a nuclear transcription factor that regulates gene expression during embryonic development and adult tissue homeostasis, particularly in liver, kidney, pancreas, and genitourinary epithelium.

HNF1B belongs to the homeodomain-containing transcription factor family and functions as either a homodimer or heterodimer with HNF1A. It binds specific DNA promoter sequences and regulates genes involved in epithelial differentiation, glucose metabolism, and organ morphogenesis. The protein contains a dimerization domain, a POU-specific DNA binding domain, and a transactivation domain that mediates transcriptional regulation of downstream targets.

During development, HNF1B plays a critical role in renal tubulogenesis, pancreatic organogenesis, and hepatobiliary differentiation. It is highly expressed in renal tubular epithelial cells, bile ducts, pancreatic ductal cells, and certain epithelial-derived tissues. Disruption of HNF1B expression alters nephron segmentation and epithelial polarity, highlighting its role in tissue architecture and functional maturation.

Clinically, mutations in HNF1B are associated with Renal cysts and diabetes syndrome, also known as MODY5, as well as congenital abnormalities of the kidney and urinary tract. Loss or altered expression has also been described in subsets of renal cell carcinoma and gynecologic malignancies. Because of its consistent nuclear localization and epithelial lineage specificity, TCF2 antibody is widely used for evaluating HNF1B expression in developmental biology and oncology research.

In normal tissues, HNF1B localizes predominantly to the nucleus, consistent with its transcription factor function. Altered nuclear expression patterns may reflect dysregulation of epithelial differentiation programs. A TCF2 antibody can be used in research applications to detect HNF1B protein expression in relevant experimental systems.

UniProt: P35680

Pathways: Hormone Transport, Stem Cell Maintenance, Tube Formation