Rekombinanter FOLR1 Antikörper

Produktnummer ABIN8093189

Der Kaninchen Monoklonal anti-FOLR1 Antikörper wird verwendet zum Nachweis von FOLR1 in Proben von Human, Maus, Ratte, Meerschweinchen und Hamster. Er wurde validiert für WB und IHC.

Kurzübersicht für Rekombinanter FOLR1 Antikörper (ABIN8093189)

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Hamster

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser FOLR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: FOLR1-12910R

Produktdetails anti-FOLR1 Antikörper

Verwendungszweck: FOLR1 Antibody / Folate receptor 1

Immunogen: A recombinant fragment of human FOLR1 protein (exact sequence is proprietary) was used as the immuongen for the FOLR1/Folate receptor alpha antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the FOLR1/Folate receptor alpha antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: FOLR1/Folate receptor alpha antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu FOLR1

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Andere Bezeichnung: FOLR1

Hintergrund: Folate receptor alpha antibody is commonly used to study Folate receptor alpha, a high-affinity folate binding protein that mediates cellular folate uptake through receptor-dependent endocytosis. Folate receptor alpha is encoded by the FOLR1 gene and belongs to a specialized class of folate transporters that operate independently of reduced folate carriers. By concentrating folate at the cell surface and facilitating internalization, Folate receptor alpha supports one-carbon metabolism, nucleotide biosynthesis, and cellular proliferation in folate-dependent tissues.

Folate receptor alpha is a glycosylphosphatidylinositol-anchored protein localized primarily to the plasma membrane, where it exhibits strong affinity for oxidized folate forms. This membrane anchoring distinguishes Folate receptor alpha from transmembrane folate transporters and contributes to its polarized distribution in epithelial cells. Studies using FOLR1 antibody have been central to defining receptor localization, ligand binding behavior, and intracellular trafficking following folate uptake.

Expression of Folate receptor alpha is normally restricted to select epithelial tissues, including placenta, kidney, and certain secretory epithelia, where it localizes to the apical cell surface. This restricted expression pattern reflects tissue-specific folate requirements and epithelial polarity. In experimental systems, detection of Folate receptor alpha using a FOLR1 antibody enables investigation of epithelial differentiation, membrane organization, and nutrient transport pathways.

Dysregulated expression of Folate receptor alpha has been widely documented in epithelial malignancies, particularly those arising from tissues that normally express FOLR1 at low levels. In these contexts, increased Folate receptor alpha expression is thought to reflect altered metabolic demand and changes in folate utilization. Use of a Folate receptor alpha antibody supports research into folate metabolism, epithelial tumor biology, and membrane-associated receptor dynamics without reliance on tumor-associated antigen nomenclature.

Folate receptor alpha antibody (clone FOLR1/12910R) is designed to detect Folate receptor alpha in research applications. Assessment of FOLR1 expression and localization provides insight into folate binding capacity, membrane-associated transport mechanisms, and tissue-specific metabolic regulation. Overall, Folate receptor alpha remains a fundamental protein for studies of folate biology, epithelial physiology, and disease-associated metabolic adaptation.

UniProt: P15328

Pathways: Dicarboxylic Acid Transport