ERG Antikörper (AA 1-300)

Produktnummer ABIN8093154

Der Maus Monoklonal anti-ERG Antikörper (Klon ERG1-12590) (ABIN8093154) detektiert spezifisch ERG in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ERG Antikörper (AA 1-300) (ABIN8093154)

Target: ERG (ERG, ETS transcription factor (ERG))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ERG Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Klon: ERG1-12590

Produktdetails anti-ERG Antikörper

Bindungsspezifität: AA 1-300

Verwendungszweck: ERG Antibody / ETS related gene (azide and preservative free)

Immunogen: A recombinant fragment (around amino acids 1-300) of human ERG (exact sequence is proprietary) was used as the immunogen for the ERG/ETS related gene antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ERG/ETS related gene antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: ERG/ETS related gene antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu ERG

Target: ERG (ERG, ETS transcription factor (ERG))

Andere Bezeichnung: ERG

Hintergrund: ERG antibody targets ETS related gene, a nuclear transcription factor encoded by the ERG gene and a member of the ETS family of transcriptional regulators. ERG plays a critical role in gene expression programs that control endothelial cell differentiation, vascular development, and hematopoietic lineage specification. Through sequence-specific DNA binding, ERG regulates transcriptional networks essential for cell identity and tissue homeostasis.

ERG is predominantly localized in the nucleus and is highly expressed in vascular endothelial cells and cells of hematopoietic origin. Its expression pattern makes ERG antibody detection particularly useful for identifying endothelial cells and assessing vascular differentiation in tissue samples. In addition, ERG expression is observed in subsets of hematologic cells, reflecting its role in blood cell development and maintenance.

Functionally, ERG regulates genes involved in cell survival, migration, and differentiation. In endothelial cells, ERG supports vascular stability and angiogenic capacity by modulating transcriptional responses to developmental and environmental cues. ERG antibody reagents therefore support investigations into transcriptional control mechanisms underlying vascular biology and endothelial cell function.

Alterations in ERG expression are associated with several disease contexts. ERG gene rearrangements and overexpression are well documented in prostate cancer, most commonly through fusion with androgen-regulated promoters, leading to aberrant transcriptional activity. ERG expression has also been implicated in certain leukemias and vascular tumors, where dysregulated transcription contributes to disease progression. These associations highlight the relevance of ERG antibody-based detection in cancer research and hematopathology studies.

Clone ERG1/12590 is designed to recognize ETS related gene in research applications. ERG antibody reagents are suitable for detecting nuclear ERG expression in endothelial and hematopoietic cells, supporting studies focused on vascular biology, transcriptional regulation, and disease-associated alterations in ETS family signaling.

UniProt: P11308