EGFL7 Antikörper (AA 1-200)

Produktnummer ABIN8093142

Der Maus Monoklonal anti-EGFL7 Antikörper (Klon EGFL7-9499) (ABIN8093142) detektiert spezifisch EGFL7 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für EGFL7 Antikörper (AA 1-200) (ABIN8093142)

Target: EGFL7 (EGF-Like-Domain, Multiple 7 (EGFL7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser EGFL7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: EGFL7-9499

Produktdetails anti-EGFL7 Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: EGFL7 Antibody / EGF-like domain-containing protein 7

Immunogen: A recombinant fragment (around amino acids 1-200) of human EGFL7 protein (exact sequence is proprietary) was used as the immunogen for the Epidermal Growth Factor-Like Protein 7/EGFL7 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Epidermal Growth Factor-Like Protein 7/EGFL7 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Epidermal Growth Factor-Like Protein 7/EGFL7 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu EGFL7

Target: EGFL7 (EGF-Like-Domain, Multiple 7 (EGFL7))

Andere Bezeichnung: EGFL7

Hintergrund: Epidermal Growth Factor-Like Protein 7 antibody, also known as EGFL7 antibody, recognizes a secreted extracellular matrix-associated protein commonly referred to as EGF-like domain-containing protein 7 and Vascular endothelial statin. Epidermal Growth Factor-Like Protein 7 is encoded by the EGFL7 gene located on chromosome 9q34 and is predominantly expressed by endothelial cells. The protein is secreted into the extracellular space, where it incorporates into the vascular basement membrane and contributes to vascular integrity and remodeling. EGFL7 expression is particularly elevated during embryonic angiogenesis and in tissues undergoing active vascular remodeling.

Epidermal Growth Factor-Like Protein 7 functions as a regulator of endothelial cell adhesion, migration, and tubule formation. It plays a key role in vascular lumen formation and stabilization of endothelial architecture. EGFL7 antibody is widely used in studies of angiogenesis, tumor-associated neovascularization, and vascular development. The protein has also been shown to modulate Notch signaling in endothelial cells, influencing vascular patterning and differentiation during development.

Structurally, Epidermal Growth Factor-Like Protein 7 contains multiple epidermal growth factor-like repeats that mediate interactions with integrins and other extracellular matrix components. Through these domains, EGFL7 supports endothelial cell-matrix communication and maintains vascular stability. Its expression is developmentally regulated, with high levels in embryonic vasculature and more restricted expression in adult tissues except during repair, inflammation, or tumor angiogenesis.

Dysregulated EGFL7 expression has been associated with cancer progression and metastasis. Increased EGFL7 levels are observed in colorectal, breast, and hepatocellular carcinomas, where enhanced angiogenesis supports tumor growth and dissemination. Because EGFL7 is largely endothelial-specific, it serves as a valuable marker for studying tumor vasculature and vascular remodeling processes. Its extracellular localization also makes it of interest in therapeutic strategies targeting angiogenesis.

Epidermal Growth Factor-Like Protein 7 antibody supports research in vascular biology, angiogenesis, and tumor microenvironment signaling. Clone EGFL7/9499 recognizes EGFL7 and is suitable for detecting Epidermal Growth Factor-Like Protein 7 expression in relevant research applications.

UniProt: Q9UHF1