DUSP2 Antikörper (AA 1-250)

Produktnummer ABIN8093135

Der Kaninchen Polyklonal anti-DUSP2 Antikörper wird verwendet zum Nachweis von DUSP2 in Proben von Human. Er wurde validiert für WB, FACS, IHC und IF.

Kurzübersicht für DUSP2 Antikörper (AA 1-250) (ABIN8093135)

Target: DUSP2 (Dual Specificity Phosphatase 2 (DUSP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DUSP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-DUSP2 Antikörper

Bindungsspezifität: AA 1-250

Verwendungszweck: DUSP2 Antibody / Dual specificity protein phosphatase 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human Dual specificity protein phosphatase 2 recombinant protein (amino acids M1-G250) was used as the immunogen for the DUSP2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the DUSP2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the DUSP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu DUSP2

Target: DUSP2 (Dual Specificity Phosphatase 2 (DUSP2))

Andere Bezeichnung: DUSP2

Hintergrund: DUSP2 antibody targets Dual specificity protein phosphatase 2, encoded by the DUSP2 gene. Dual specificity protein phosphatase 2, also called Dual specificity protein phosphatase PAC-1 or PAC1, is a cytoplasmic and nuclear enzyme that belongs to the family of dual-specificity phosphatases, which dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. DUSP2 is best known for its role in regulating mitogen-activated protein kinase signaling by directly modulating MAP kinase phosphorylation status.

Functionally, Dual specificity protein phosphatase 2 acts as a negative regulator of MAPK pathways, particularly those involving ERK and p38 signaling. By dephosphorylating activated MAP kinases, DUSP2 controls signal intensity and duration, ensuring appropriate cellular responses to extracellular stimuli. A DUSP2 antibody supports studies focused on signal transduction, kinase regulation, and immune-related signaling pathways.

DUSP2 expression is enriched in immune cells, including lymphocytes, where it plays an important role in regulating activation, proliferation, and inflammatory responses. Its expression pattern reflects a specialized function in immune signaling rather than ubiquitous housekeeping activity. Subcellular localization of DUSP2 can shift between the cytoplasm and nucleus depending on activation state and signaling context.

From a disease-relevance perspective, Dual specificity protein phosphatase 2 has been investigated in inflammatory disorders, autoimmune disease, and cancer. Altered DUSP2 expression or activity can lead to prolonged MAPK signaling, contributing to dysregulated immune responses and abnormal cell growth. As a result, DUSP2 is considered an important regulatory node in pathways that balance activation and suppression of cellular signaling.

At the molecular level, Dual specificity protein phosphatase 2 contains a conserved catalytic phosphatase domain and regulatory regions that mediate interaction with MAP kinases. Post-translational modifications and cellular context can influence its activity and apparent behavior in biochemical assays without altering the primary amino acid sequence. DUSP2 antibody reagents support research applications focused on MAPK signaling regulation and immune cell biology, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q05923