Rekombinanter CALB1 Antikörper

Produktnummer ABIN8093023

Dieser Maus Monoklonal Antikörper detektiert spezifisch CALB1 in IHC und WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter CALB1 Antikörper (ABIN8093023)

Target: CALB1 (Calbindin (CALB1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CALB1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Klon: RCALB1-9805

Produktdetails anti-CALB1 Antikörper

Verwendungszweck: Calbindin Antibody / CALB1

Immunogen: A recombinant fragment corresponding human CALB1 protein was used as the immunogen for the D28K/CALB1 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: 1. Optimal dilution of the D28K/CALB1 antibody should be determined by the researcher.

2. This D28K/CALB1 antibody is recombinantly produced by expression in CHO cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: CALB1/Vitamin D-dependent calcium-binding protein antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu CALB1

Target: CALB1 (Calbindin (CALB1))

Andere Bezeichnung: Calbindin

Hintergrund: D28K antibody, also known as CALB1 antibody, recognizes D28K, a widely used abbreviated name for the calcium-binding protein Calbindin 1 encoded by the CALB1 gene. The D28K designation reflects the approximate 28 kDa molecular size of this EF-hand calcium-binding protein and is commonly used in western blot figures, neuronal marker studies, and calcium signaling research. D28K functions as an intracellular calcium buffer that modulates the amplitude and kinetics of calcium transients, thereby shaping downstream signaling responses in excitable and secretory cells.

D28K is a member of the calbindin subfamily within the larger EF-hand protein family and contains six EF-hand motifs, four of which are capable of binding Ca2+ with high affinity. By reversibly binding calcium ions, D28K influences intracellular diffusion of calcium and limits cytotoxic calcium overload. This buffering activity is particularly important in cells exposed to rapid calcium flux, such as neurons and endocrine cells. Altered expression of CALB1 has been associated with dysregulated calcium homeostasis in neurodegenerative disorders, where reduced D28K levels may contribute to increased cellular susceptibility to stress and excitotoxic injury.

In the nervous system, D28K expression is frequently examined in the context of neuronal circuit mapping, interneuron characterization, and studies of synaptic plasticity. Outside the brain, CALB1 expression is detected in kidney distal tubular epithelium, intestinal absorptive cells, and pancreatic islets, where it supports calcium transport and hormone secretion processes. Because D28K is often cited in abbreviated form in primary research articles and figure legends, D28K antibody provides a convenient and literature-consistent terminology for investigators working with calcium-binding protein pathways. Clone rCALB1/9805 is a recombinant mouse monoclonal antibody generated through defined sequence expression, supporting lot-to-lot consistency and reproducibility in research applications focused on calcium regulation and cell type identification.

UniProt: P05937