Peptide Histidine-Methionine Antikörper

Produktnummer ABIN8065516

Der Maus Monoklonal anti-Peptide Histidine-Methionine Antikörper (Klon 3) (ABIN8065516) detektiert spezifisch Peptide Histidine-Methionine in ELISA und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Peptide Histidine-Methionine Antikörper (ABIN8065516)

Target: Peptide Histidine-Methionine (PHM)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Peptide Histidine-Methionine Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Klon: 3

Produktdetails anti-Peptide Histidine-Methionine Antikörper

Verwendungszweck: Anti-Peptide Histidine Methionine Antibody

Spezifität: ABS 020-03 binds human PHM and cross-reacts with PACAP (approximately 12 % , incomplete, non-parallel inhibition). ABS 020-03 does not cross-react with GLP-1, GLP-2, VIP or glucagon.

Homologie: Human

Aufreinigung: Protein A or Protein G purified

Immunogen: Synthetic human peptide histidine-methionine

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C without exposure to light

Haltbarkeit: 24 months

Details zu Peptide Histidine-Methionine

Target: Peptide Histidine-Methionine (PHM)

Andere Bezeichnung: Peptide Histidine Methionine

Hintergrund: VIP, PHM27, VIP peptides, prepro-VIP,[Vasoactive intestinal peptide]: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2) (PubMed:1318039, PubMed:36385145, PubMed:8933357). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (PubMed:3456568). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (PubMed:15013843). {ECO:0000269|PubMed:1318039, ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3456568, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8933357}., [Intestinal peptide PHM-27]: Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (PubMed:15013843). {ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3654650}., [Intestinal peptide PHV-42]: Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). {ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3654650}.,VIP,Human peptide histidine-methionine (PHM) is a 27 amino acid peptide belonging to the glucagon-secretin family of peptide hormones. PHM is produced from the same prohormone as VIP, with which it shows considerable sequence homology. The VIP/PHM prohormone is produced by neurons in the central and peripheral nervous systems, often together with acetylcholine. In some situations the effect of the peptides is to reinforce and prolong the effects of neurotransmitter release. Like VIP, PHM is a vasodilator and stimulator of intestinal fluid secretion. High plasma levels of PHM are diagnostic of the corresponding peptide-producing tumor (VIPoma), associated with the watery diarrhea-hypokalemia-achlorhydria syndrome.

Molekulargewicht: 3 kDa

Gen-ID: 7432

UniProt: P01282