OXM Antikörper

Produktnummer ABIN8065514

Dieser Maus Monoklonal Antikörper detektiert spezifisch OXM in ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für OXM Antikörper (ABIN8065514)

Target: OXM (Oxyntomodulin (OXM))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser OXM Antikörper ist unkonjugiert

Applikation: ELISA

Güteklasse: Carrier-free

Klon: 46

Produktdetails anti-OXM Antikörper

Verwendungszweck: Anti-Oxyntomodulin Antibody

Spezifität: ABS 064-46 is specific for C-terminus of human oxyntomodulin. Does not cross-react with glucagon. ABS 064-46 has a different epitope specificity compared to ABS 064-23 and ABS 059-20.

Homologie: Human,Mouse,and Rat

Aufreinigung: Protein A or Protein G purified

Immunogen: Synthetic oxyntomodulin 31-37 coupled to carrier.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C without exposure to light

Haltbarkeit: 24 months

Details zu OXM

Target: OXM (Oxyntomodulin (OXM))

Andere Bezeichnung: Oxyntomodulin

Hintergrund: GCG, GLP-1, GLP1, GLP2, GRPP, pro-glucagon, glicentin-related polypeptide, glucagon-like peptide 1, glucagon-like peptide 2, incretin, preproglucagon,Glucagon-like peptide 1. Potent stimulator of glucose-dependent insulin release (PubMed:22037645, PubMed:40446798). Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels (PubMed:10605628, PubMed:14719035, PubMed:12554744). May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin (PubMed:10605628, PubMed:14719035, PubMed:12554744). Has growth-promoting activities on intestinal epithelium (PubMed:10605628, PubMed:14719035, PubMed:12554744). May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion (PubMed:10605628, PubMed:14719035, PubMed:12554744). Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation (PubMed:10605628, PubMed:14719035, PubMed:12554744). Inhibits beta cell apoptosis (PubMed:10605628, PubMed:14719035, PubMed:12554744).,GCG,Oxyntomodulin is a peptide hormone of 37 amino-acid residues (29-amino acid sequence of glucagon, with an 8-amino acid carboxy-terminal extension) produced by the L cells of the gut. It modulates gastric acid secretion from the oxyntic cells of the stomach, inhibits appetite and has glucose lowering effects. Oxyntomodulin is produced by cell-type-specific processing of proglucagon that forms as well glicentin, GLP-1 and GLP-2 in the L cells of the intestinal mucosa.

Molekulargewicht: 20 kDa

Gen-ID: 2641

UniProt: P01275