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TDP2 Antikörper (AA 201-300) (Biotin)

Dieses Anti-TDP2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TDP2 in WB, ELISA, IHC (p) und IHC (fro). Geeignet für Maus.
Produktnummer ABIN755784

Kurzübersicht für TDP2 Antikörper (AA 201-300) (Biotin) (ABIN755784)

Target

Alle TDP2 Antikörper anzeigen
TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))

Reaktivität

  • 49
  • 30
  • 9
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Maus

Wirt

  • 47
  • 16
Kaninchen

Klonalität

  • 49
  • 14
Polyklonal

Konjugat

  • 29
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TDP2 Antikörper ist konjugiert mit Biotin

Applikation

  • 48
  • 26
  • 26
  • 21
  • 21
  • 13
  • 13
  • 10
  • 8
  • 6
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 14
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-300

    Kreuzreaktivität

    Maus

    Homologie

    Human,Rat,Dog,Cow,Pig,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human ETS1 associated protein II/EAPII

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))

    Andere Bezeichnung

    ETS1 associated protein 2

    Hintergrund

    Synonyms: EAP 2, EAP II, EAP2, EAPII, ETS 1 associated protein 2, ETS 1 associated protein II, ETS1 associated protein 2, ETS1-associated protein 2, ETS1-associated protein II, tdp2, TRAF and TNF receptor associated protein, TRAF and TNF receptor-associated protein, TTRAP, TYDP2_HUMAN, Tyr DNA phosphodiesterase 2, Tyr-DNA phosphodiesterase 2, Tyrosyl DNA phosphodiesterase 2, Tyrosyl-DNA phosphodiesterase 2, 5''-Tyr-DNA phosphodiesterase, 5''-tyrosyl-DNA phosphodiesterase, AD 022, AD022, MGC111021, MGC9099.

    Background: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.

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