Utrophin Antikörper (AA 1211-2294) (HRP)

Produktnummer ABIN8052945

Der Kaninchen Polyklonal anti-Utrophin Antikörper wird verwendet zum Nachweis von Utrophin in Proben von Human und Maus. Er wurde validiert für WB, IHC und ELISA.

Kurzübersicht für Utrophin Antikörper (AA 1211-2294) (HRP) (ABIN8052945)

Target: Utrophin (UTRN)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Utrophin Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Utrophin Antikörper (HRP)

Bindungsspezifität: AA 1211-2294

Verwendungszweck: Anti-Utrophin/UTRN Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Utrophin/UTRN recombinant protein (Position: L1211-K2294).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Utrophin

Target: Utrophin (UTRN)

Andere Bezeichnung: UTRN

Hintergrund:

Background: Utrophin is a protein that in humans is encoded by the UTRN gene. This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described, however, the full-length nature of these variants has not yet been determined.

Gene Full Name: utrophin

Gen-ID: 7402

UniProt: P46939

Pathways: Skeletal Muscle Fiber Development