ZEB1/2 Antikörper (AA 211-320)

Produktnummer ABIN755113

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ZEB1/2 in WB, FACS und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für ZEB1/2 Antikörper (AA 211-320) (ABIN755113)

Target: ZEB1/2 (ZEB1, ZEB2)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZEB1/2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Produktdetails anti-ZEB1/2 Antikörper

Bindungsspezifität: AA 211-320

Spezifität: Antibody will bind to Zinc finger E-box-binding homeobox 1 & 2

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZEB1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-ZEB1/2 Antikörper (ABIN755113)

He, Lu, Hu, Zhang, Qin, Wang, Xing, Xi, Wang: "The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation." in: International journal of molecular sciences, Vol. 16, Issue 7, pp. 16313-29, (2016) (PubMed).

Xiang, Liu, Chen, Wang, Ma, Wu, Gao: "ZEB1 Expression Is Correlated With Tumor Metastasis and Reduced Prognosis of Breast Carcinoma in Asian Patients." in: Cancer investigation, Vol. 33, Issue 6, pp. 225-31, (2015) (PubMed).

Sasaki, Kuniyasu, Luo, Kato, Shinya, Fujii, Ohmori, Yamashita: "Significance of epithelial growth factor in the epithelial-mesenchymal transition of human gallbladder cancer cells." in: Cancer science, Vol. 103, Issue 6, pp. 1165-71, (2012) (PubMed).

Details zu ZEB1/2

Target: ZEB1/2 (ZEB1, ZEB2)

Andere Bezeichnung: ZEB1/2

Hintergrund:

Synonyms: AREB 6, AREB6, BZP, Delta crystallin enhancer binding factor 1, DELTA EF1, FECD6, MGC133261, Negative regulator of IL 2, Negative regulator of IL2, NIL 2 A, NIL 2 A zinc finger protein, NIL 2A, NIL-2-A zinc finger protein, NIL2A, Posterior polymorphous corneal dystrophy 3, PPCD3, Represses interleukin 2 expression, TCF 8, TCF-8, TCF8, Transcription factor 8 represses interleukin 2 expression, Transcription factor 8, ZEB 1, ZEB, ZEB1, ZEB1_HUMAN, ZFHEP, ZFHX 1A, ZFHX1A, Zinc finger E box binding homeobox 1, Zinc finger E-box-binding homeobox 1, Zinc finger homeodomain enhancer binding protein, Smad Interacting Protein 1 SIP 1, SIP1 SIP-1, Smad-interacting protein 1, SMADIP 1, SMADIP1, ZEB 2, ZEB2, ZEB2_HUMAN, Zfhx1b, ZFHX1B protein, Zfx1b, Zinc finger E box binding protein 2, Zinc finger E-box-binding homeobox 2, Zinc finger homeobox 1b, zinc finger homeobox protein 1, Zinc finger homeobox protein 1b.

Background: ZEB1 Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. ZEB2 is a Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.

Gen-ID: 6935, 9839

UniProt: P37275, O60315