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RPH3AL Antikörper (AA 25-130) (Biotin)

RPH3AL Reaktivität: Maus WB, ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN755055
  • Target Alle RPH3AL Antikörper anzeigen
    RPH3AL (Rabphilin 3A-Like (Without C2 Domains) (RPH3AL))
    Bindungsspezifität
    • 15
    • 14
    • 9
    • 8
    • 7
    • 6
    • 1
    AA 25-130
    Reaktivität
    • 40
    • 14
    • 1
    • 1
    Maus
    Wirt
    • 54
    Kaninchen
    Klonalität
    • 54
    Polyklonal
    Konjugat
    • 13
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser RPH3AL Antikörper ist konjugiert mit Biotin
    Applikation
    • 51
    • 26
    • 26
    • 24
    • 15
    • 8
    • 5
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human RPH3AL
    Isotyp
    IgG
    Top Product
    Discover our top product RPH3AL Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    RPH3AL (Rabphilin 3A-Like (Without C2 Domains) (RPH3AL))
    Andere Bezeichnung
    RPH3AL (RPH3AL Produkte)
    Synonyme
    NOC2 antikoerper, 6530413F01Rik antikoerper, AI551877 antikoerper, Gm1753 antikoerper, Noc2 antikoerper, rabphilin 3A like (without C2 domains) antikoerper, rabphilin 3A-like (without C2 domains) antikoerper, RPH3AL antikoerper, Rph3al antikoerper
    Hintergrund

    Synonyms: Noc2, Rab effector Noc2, Rabphilin 3A-like without C2 domains, Rabphilin 3A-like, Rabphilin-3A-like protein, RPH3AL, RPH3L_HUMAN, No C2 domains protein, Gm1753.

    Background: Rabphilin-3AL (rabphilin-3A-like), also known as RPH3AL or NOC2, is a cytoplasmic Rab GTPase effector. It contains one FYVE-type zinc finger and one Rab-binding (RBD) domain, but unlike its related protein, rabphilin-3A, rabphilin-3AL does not contain any C2 domains. Rabphilin-3AL is expressed in a variety of tissues, with highest levels found in kidney, skeletal muscle, pancreas, liver, ovary, stomach, heart and thyroid. It is believed to play a role regulating calcium-dependent secretory vesicle exocytosis in endocrine and exocrine cells. Via its RBD domain, rabphilin-3AL is capable of binding Rab 27a and, through this interaction, rabphilin-3AL is recruited to dense-core vesicles. With lower affinity, rabphilin-3AL can also bind Rab 3 and Rab 8 with its RBD domain. Through an interaction with Rab 3, rabphilin-3AL can inhibit G-protein signaling in endocrine pancreas and positively regulate insulin secretion. Rabphilin-3AL knockout mice display accumulation of secretory granules and irregular shape in exocrine cells.

    Gen-ID
    9501
    Pathways
    Carbohydrate Homeostasis, Regulation of G-Protein Coupled Receptor Protein Signaling
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