TBC1D4 Antikörper (AA 1118-1298) (Fluoro594)

Produktnummer ABIN8045556

Der Kaninchen Polyklonal anti-TBC1D4 Antikörper wird verwendet zum Nachweis von TBC1D4 in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für TBC1D4 Antikörper (AA 1118-1298) (Fluoro594) (ABIN8045556)

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBC1D4 Antikörper ist konjugiert mit Fluoro594

Applikation: Flow Cytometry (FACS)

Produktdetails anti-TBC1D4 Antikörper (Fluoro594)

Bindungsspezifität: AA 1118-1298

Verwendungszweck: Anti-AS160/TBC1D4 Antibody Fluoro594 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human TBC1D4 recombinant protein (Position: K1118-P1298).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu TBC1D4

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Andere Bezeichnung: TBC1D4

Hintergrund:

Background: AS160 (Akt substrate of 160 kDa), which was originally known asTBC1 domain family member 4 (TBC1D4),is a RabGTPase-activatingproteinthat in humans is encoded by theTBC1D4gene. This gene is a member of the Tre-2/BUB2/CDC16 domain family. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion.

Gene Full Name: TBC1 domain family member 4

Gen-ID: 9882

UniProt: O60343