TACR1 Antikörper (Middle Region) (HRP)

Produktnummer ABIN8045184

Der Kaninchen Polyklonal anti-TACR1 Antikörper wird verwendet zum Nachweis von TACR1 in Proben von Human, Ratte und Maus. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für TACR1 Antikörper (Middle Region) (HRP) (ABIN8045184)

Target: TACR1 (Tachykinin Receptor 1 (TACR1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TACR1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-TACR1 Antikörper (HRP)

Bindungsspezifität: Middle Region

Verwendungszweck: Anti-Neurokinin 1 Receptor/TACR1 Antibody HRP Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: identical to the related rat,mouse sequences.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TACR1, identical to the related rat and mouse sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu TACR1

Target: TACR1 (Tachykinin Receptor 1 (TACR1))

Andere Bezeichnung: TACR1

Hintergrund:

Background: The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.

Gene Full Name: tachykinin receptor 1

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Gen-ID: 6869

UniProt: P25103

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration