SENP6 Antikörper (AA 135-1086)

Produktnummer ABIN8043522

Der Kaninchen Polyklonal anti-SENP6 Antikörper wird verwendet zum Nachweis von SENP6 in Proben von Human. Er wurde validiert für ELISA und WB.

Kurzübersicht für SENP6 Antikörper (AA 135-1086) (ABIN8043522)

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SENP6 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Güteklasse: Carrier-free

Produktdetails anti-SENP6 Antikörper

Bindungsspezifität: AA 135-1086

Verwendungszweck: Anti-SENP6 Antibody

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-SENP6.Antibody-3. Tested in ELISA, WB applications. This antibody reacts with Human.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SENP6 recombinant protein (Position: R135-K1086).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Andere Bezeichnung: SENP6

Hintergrund:

Background: Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene. It is mapped to 6q14.1. Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins. SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates.

Gene Full Name: SUMO specific peptidase 6

Molekulargewicht: 150 kDa

Gen-ID: 26054

UniProt: Q9GZR1