SENP6 Antikörper (AA 135-1086) (Fluoro488)

Produktnummer ABIN8043514

Der Fluoro488-konjugierte Kaninchen Polyklonal anti-SENP6 Antikörper (ABIN8043514) detektiert spezifisch SENP6 in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für SENP6 Antikörper (AA 135-1086) (Fluoro488) (ABIN8043514)

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SENP6 Antikörper ist konjugiert mit Fluoro488

Applikation: Flow Cytometry (FACS)

Produktdetails anti-SENP6 Antikörper (Fluoro488)

Bindungsspezifität: AA 135-1086

Verwendungszweck: Anti-SENP6 Antibody Fluoro488 Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SENP6 recombinant protein (Position: R135-K1086).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Andere Bezeichnung: SENP6

Hintergrund:

Background: Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene. It is mapped to 6q14.1. Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins. SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates.

Gene Full Name: SUMO specific peptidase 6

Gen-ID: 26054

UniProt: Q9GZR1