STAMBPL1 Antikörper (AA 187-436) (HRP)

Produktnummer ABIN8042502

Der Kaninchen Polyklonal anti-STAMBPL1 Antikörper wird verwendet zum Nachweis von STAMBPL1 in Proben von Human und Maus. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für STAMBPL1 Antikörper (AA 187-436) (HRP) (ABIN8042502)

Target: STAMBPL1 (STAM Binding Protein-Like 1 (STAMBPL1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAMBPL1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-STAMBPL1 Antikörper (HRP)

Bindungsspezifität: AA 187-436

Verwendungszweck: Anti-AMSH-LP/STAMBPL1 Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human AMSH-LP/STAMBPL1 recombinant protein (Position: Q187-R436).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu STAMBPL1

Target: STAMBPL1 (STAM Binding Protein-Like 1 (STAMBPL1))

Andere Bezeichnung: STAMBPL1

Hintergrund:

Background: STAMBPL1 (STAM-binding protein-like 1), also known as AMSH-FP, AMSH-LP (associated molecule with the SH3 domain of STAM like protein) or ALMa, is a 436 amino acid protein that belongs to the peptidase M67C family, contains one MPN domain and a JAMM motif that is essential for protease activity. Existing as two alternatively spliced isoforms, STAMBPL1 is a ubiquitously expressed protein that binds two zinc ions per subunit and acts as a zinc metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains. The gene that encodes STAMBPL1 maps to human chromosome 10q23.31. Chromosome 10 contains over 800 genes and 135 million nucleotides, making up nearly 4.5 % of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10.

Gene Full Name: STAM binding protein like 1

Gen-ID: 57559

UniProt: Q96FJ0