SHBG Antikörper (AA 30-210) (Fluoro550)

Produktnummer ABIN8036824

Der Fluoro550-konjugierte Kaninchen Polyklonal anti-SHBG Antikörper (ABIN8036824) detektiert spezifisch SHBG in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für SHBG Antikörper (AA 30-210) (Fluoro550) (ABIN8036824)

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SHBG Antikörper ist konjugiert mit Fluoro550

Applikation: Flow Cytometry (FACS)

Produktdetails anti-SHBG Antikörper (Fluoro550)

Bindungsspezifität: AA 30-210

Verwendungszweck: Anti-Sex Hormone Binding Globulin/SHBG Antibody Fluoro550 Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human SHBG shares 72% amino acid (aa) sequence identity with both mouse,rat SHBG.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SHBG recombinant protein (Position: L30-A210). Human SHBG shares 72% amino acid (aa) sequence identity with both mouse and rat SHBG.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu SHBG

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Andere Bezeichnung: SHBG

Hintergrund:

Background: Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to the sex hormones,androgen and estrogen. SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce SHBG include the brain, uterus, testes, and placenta. SHBG has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. High estrogen, andthyroxine cause it to increase. It has been found that the monosaccharides glucose and fructose reduced human SHBG production by hepatocytes, irrespective of the presence of insulin, by downregulation of hepatocyte nuclear factor-4A and replacement of HNF4A by COUP-TFI at a cis-element within the human SHBG promoter, coincident with repression of its transcriptional activity.

Gene Full Name: sex hormone binding globulin

Sequence Similarities: Contains 2 laminin G-like domains.

Gen-ID: 6462

UniProt: P04278

Pathways: Hormone Transport